ラットの自発運動量と、高脂肪食、血中脂質との関係

Relationship between voluntary movement, high-fat diet, and blood lipid in rats


黒木由希子	青木貴子
Yukiko KUROKI	Takako AOKI

Abstract

　　 We studied blood lipid in 60-week old rats. The 10-week old rats were divided into 4 groups: sedentary + control diet (SC), sedentary + high-fat diet (SF), exercise + control diet (EC), and exercise + high-fat diet (EF). Rats in exercise group ran on wheel voluntarily during 50 weeks. Voluntary movement was not differ between EC and EF. Body weight of the rats at 58-week old was higher in sedentary group than in exercise group. In exercise group, it was higher in EF (579g) than in EC (475g). Serum LDL-cholesterol was also higher in EF (57.7md/dl) than in EC(35.3). Serum LDL-cholesterol in EF did not differ between that in SC (59.9) or SF (57.9). Serum triglyceride in EF was also higher (72.8mg/dl) than in EC (34.6) and rather higher than in SC (52.4) or SF (63.7). Serum HDL-cholesterol was 26mg/dl in SC, 24 in SF, 23 in EC, and 22 in EF. From these result, we conclude that rat voluntary movement does not counteract long-term high-fat diet for serum lipid.

Key words : 血清コレステロール、中性脂肪、運動、高脂肪食